Peer-reviewed study
GLP-1 body-composition changes need a muscle plan
Effect of GLP-1 receptor agonists on body composition
Kris Oddo, NASM-certified personal trainer, is the founder and head coach of Gains From Geebs (Geebs Coaching), a 1:1 online fitness coaching practice.
Quick answer
What this study found
If your weight is changing quickly on a GLP-1, plan for resistance training, adequate protein, and strength tracking rather than reacting with fear.
How strong is this kind of study?
- Reviews of many studies
- Controlled trials
- Observational
- Narrative reviewsThis study
Clinical review. Heavier plates are built from more studies, so they move less when the next one lands.
At a glance
What kind of study this is
Early or limited evidence
A review, a lab study, or an analysis of collected data. Useful for direction, not strong enough to settle a question.
- Design
- Clinical review
- Published
- 2025
- Journal
- Current Opinion in Endocrinology, Diabetes, and Obesity
- Reference
- PMID 41076575
Honest limits
What this study does not prove.
This review does not provide personal GLP-1 dosing, contraindication, or side-effect guidance; those decisions belong in clinician-led care.
Kris's practical takeaway
Here's what to do with it.
If your weight is changing quickly on a GLP-1, plan for resistance training, adequate protein, and strength tracking rather than reacting with fear.
If you are losing weight
What this means if you're losing weight.
On a GLP-1, about a quarter of the weight that comes off is lean mass. Lifting and enough protein are what you control: they decide how much of the rest is fat. The medication stays with your prescriber.
Ways to use it
Safe ways to apply it.
Weight loss still needs a muscle strategy
Do not let appetite suppression become under-fueling
Track strength while the scale drops
Related guides and studies
Keep learning about peptides.
FAQ
Quick questions
What is the practical takeaway from this study?
If your weight is changing quickly on a GLP-1, plan for resistance training, adequate protein, and strength tracking rather than reacting with fear.
What does this study not prove?
This review does not provide personal GLP-1 dosing, contraindication, or side-effect guidance; those decisions belong in clinician-led care.
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25 lbAverage fat loss across 15 completed clients tracked over 16 weeks. Individual results vary.
1 of 3
2 months coachedDown 10 pounds and carrying more confidence into daily life.
Justin · 24 · 2 months coached“I've lost 10 lb, which has definitely given me more confidence. I'm not as tired during work and I can lift things easier than before.”
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6 months coachedFrom zero pull-ups to five on his own.
Jon Miller · 27 · 6 months coached“Before I couldn't do a single pull-up, and now I can do five all on my own.”
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3 months coachedBetter technique, better health, and support to keep going.
Jhoan Rincon · 46 · 3 months coached“Kris changed the way I view my life. Even though I do not have much free time, he helps me push myself to keep going and never lets me give up.”
See the full storyWays to work with Kris
Pick the one that fits your week.
You have read the argument. These are the options, and whichever one you pick carries into the application.
1 of 5
Most hands-onYou want a coach on training, food and accountability every day.- Daily replies, usually within the hour
- FaceTime meal prep: cook, portion, freeze the week
- Fully custom plan with Kris's own demo videos
Core 1:1You want a coach with you daily, without the concierge layer.- Custom training plan with demo videos
- Macros-based nutrition, no rigid meal plan
- Daily accountability at standard priority
New, self-drivenYou run your own week and want a coach reading the numbers.- Custom training and nutrition plan
- One recorded Loom review of your week
- Adjustments based on what the week showed
One-time guidanceYou want direction now without a monthly commitment.- A focused 45-minute Zoom with Kris
- A real diagnosis of what is holding back progress right now
- Guidance on training, nutrition, accountability, or schedule
Community membershipYou want a serious fitness community without a coaching contract.- Access to the Titan Forge Science-Based Telegram community
- Training, nutrition, recovery, and research discussion
- Shared accountability with like-minded lifters