Peer-reviewed study
Protein evidence is thinner in medically complex adults
Evidence on protein intake on lean body mass and function in community-dwelling adults aged 50 years and over living with multiple long-term conditions: Systematic review
Kris Oddo, NASM-certified personal trainer, is the founder and head coach of Gains From Geebs (Geebs Coaching), a 1:1 online fitness coaching practice.
Quick answer
What this study found
Keep the protein floor practical, but be honest when evidence is limited for older adults with multiple conditions.
How strong is this kind of study?
- Reviews of many studiesThis study
- Controlled trials
- Observational
- Narrative reviews
Systematic review. Heavier plates are built from more studies, so they move less when the next one lands.
At a glance
What kind of study this is
Strongest evidence
This pools results from many separate studies, so it carries more weight than any single trial on its own.
- Design
- Systematic review
- Published
- 2026
- Journal
- Clinical Nutrition ESPEN
- Reference
- PMID 42105861
Honest limits
What this study does not prove.
The review found limited and indirect evidence, especially for older adults with multiple medical conditions.

Kris's practical takeaway
Here's what to do with it.
Keep the protein floor practical, but be honest when evidence is limited for older adults with multiple conditions.
Ways to use it
Safe ways to apply it.
Protein advice still needs context
Protein still has limits
A steady protein target beats a magic macro
Related questions
Questions this research helps answer.
Protein and recomp answer
How much protein do you need for body recomposition?
Protein is one of the most reliable supports for body recomposition, but it is not magic by itself. Training creates the adaptation signal; protein helps support satiety, recovery, and lean-mass retention while calories are managed.
Protein and aging answer
Does protein help preserve muscle as you age?
Protein is a useful floor to protect as you age, but it is not enough by itself. Pair it with resistance training, enough calories for your current goal, and medical guidance when health conditions affect your needs.
Related guides and studies
Keep learning about nutrition.
FAQ
Quick questions
What is the practical takeaway from this study?
Keep the protein floor practical, but be honest when evidence is limited for older adults with multiple conditions.
What does this study not prove?
The review found limited and indirect evidence, especially for older adults with multiple medical conditions.
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