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Peer-reviewed study

Fat loss and muscle loss must be separated

Effect of Incretin-Based and Nonpharmacologic Weight Loss on Body Composition: A Systematic Review

PeptidesSystematic review2026
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PubMed sourceMore Peptides researchHow to read the studies

Kris Oddo, NASM-certified personal trainer, is the founder and head coach of Gains From Geebs (Geebs Coaching), a 1:1 online fitness coaching practice.

Quick answer

What this study found

When your weight is moving quickly, track strength, protein intake, daily function, and body-composition trends instead of watching the scale alone.

How strong is this kind of study?

  1. Reviews of many studiesThis study
  2. Controlled trials
  3. Observational
  4. Narrative reviews

Systematic review. Heavier plates are built from more studies, so they move less when the next one lands.

At a glance

What kind of study this is

Strongest evidence

This pools results from many separate studies, so it carries more weight than any single trial on its own.

Design
Systematic review
Published
2026
Journal
Annals of Internal Medicine
Reference
PMID 41996180

Source details

Who ran it, and where to read it.

Authors
Batsis et al.
PubMedDOI

Honest limits

What this study does not prove.

A home scale cannot diagnose muscle loss. Body-composition methods vary, and medical interpretation belongs with clinicians.

Kris Oddo, NASM-CPT, in the gym
Kris Oddo, NASM-CPT. The study is the evidence; the paragraph below is what he actually does with it.

Kris's practical takeaway

Here's what to do with it.

When your weight is moving quickly, track strength, protein intake, daily function, and body-composition trends instead of watching the scale alone.

Ways to use it

Safe ways to apply it.

Fast weight loss needs more than a scale

Track what the scale cannot tell you

Function is part of the outcome

Related questions

Questions this research helps answer.

Strength tracking answer

Should you track strength while losing weight?

Yes. Strength tracking gives you a practical signal the scale cannot. If weight is dropping but strength, energy, and protein consistency are collapsing, the plan may be costing too much muscle and function.

Related guides and studies

Keep learning about peptides.

Peptides studiesGlp 1 Muscle Preservation StudiesShould You Track Strength While Losing WeightHow Do You Avoid Losing Muscle While Dieting

FAQ

Quick questions

What is the practical takeaway from this study?

When your weight is moving quickly, track strength, protein intake, daily function, and body-composition trends instead of watching the scale alone.

What does this study not prove?

A home scale cannot diagnose muscle loss. Body-composition methods vary, and medical interpretation belongs with clinicians.

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25 lbAverage fat loss across 15 completed clients tracked over 16 weeks. Individual results vary.

1 of 3

Justin's coaching result shared with permission2 months coached

Down 10 pounds and carrying more confidence into daily life.

Justin · 24 · 2 months coached

“I've lost 10 lb, which has definitely given me more confidence. I'm not as tired during work and I can lift things easier than before.”

See the full storyJon Miller's coaching result shared with permission6 months coached

From zero pull-ups to five on his own.

Jon Miller · 27 · 6 months coached

“Before I couldn't do a single pull-up, and now I can do five all on my own.”

See the full storyJhoan Rincon's coaching result shared with permission3 months coached

Better technique, better health, and support to keep going.

Jhoan Rincon · 46 · 3 months coached

“Kris changed the way I view my life. Even though I do not have much free time, he helps me push myself to keep going and never lets me give up.”

See the full story

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